NEW GENERATION MEDICINE FOR TREATMENT OF HEPATITIS B, POPULAR NOW

15/05/2024
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Hepatitis B is a disease that requires early detection and integrated treatment to prevent dangerous complications. Below is a list of the most popular new generation hepatitis B treatment drugs today. Patients should note that the drugs mentioned in the article are for reference only and their use requires a specialist’s prescription.

1. Overview of drugs to treat hepatitis B
With acute hepatitis B, treatment is mainly symptomatic to fight the infection. As for chronic hepatitis B, doctors will prescribe medication or a liver transplant for treatment.

Common hepatitis B treatment drugs include two forms: peginterferon alfa-2a and antiviral drugs.

-Peginterferon alfa-2a helps stimulate the immune system to attack and control HBV. The drug is used for 48 weeks by injection once a week.

-Hepatitis B antiviral drugs are used in cases where the immune system cannot control HBV on its own, and there is evidence of ongoing liver damage. This group of drugs is prepared in tablet form so it is very easy to use.

In addition, antiviral drugs also help control HBV replication and prevent it from damaging the liver. The virus may not be completely eliminated after taking the medicine. Therefore, in certain cases, medication will be required for long-term treatment, possibly even for life.

2. Medicines to treat hepatitis B for adults
Currently, there are 4 new and approved drugs for the treatment of hepatitis B in adults. These are all medications in pill form, taken for a long time or sometimes for life. In addition, doctors can prescribe immunomodulatory Interferon drugs such as Pegylated Interferon and Interferon Alpha.

-Tenofovir disoproxil fumarate (TDF) – new generation hepatitis B treatment drug

Tenofovir Mylan – New generation hepatitis B treatment drug

The dosage of the drug is 300mg/day. Particularly for people with kidney failure, the dosage needs to be adjusted according to glomerular filtration rate. Side effects of the drug may include lactic acidosis, kidney disease, Fanconi syndrome, osteoporosis syndrome.

TDF can be prescribed for pregnant women, children from 3 years old and co-infected with HBV/HIV

-Entecavir (ETV)

Patients take 0.5 mg/day or 1 mg/day (if they have ever used lamividine or have decompensated cirrhosis). Dosage is also adjusted for people with kidney failure according to glomerular filtration rate. Lactic acidosis is a possible side effect when using ETV.

-Tenofovir alafenamide (TAF)

Patients with hepatitis B use TAF at a dose of 25mg/day. Patients with kidney failure (mild, moderate or severe) or dialysis do not need to adjust the dose of the drug.

TAF is not recommended for pregnant women. The drug is the preferred choice for people over 60 years old, with kidney failure, on hemodialysis or with osteoporosis. TAF can cause lactic acidosis as a side effect and is not indicated in cases of decompensated cirrhosis.

-Peginterferon alfa-2a

This is a drug considered to be prescribed for patients who want short-term treatment and do not want long-term treatment with Nas. In addition, patients co-infected with hepatitis D or with low viral load and high ALT may also be prescribed Peginterfron alfa-2a.

The dosage for adults is 180 mcg/week. Some unwanted side effects that may be encountered are fatigue, flu-like symptoms, leukopenia, immune disorders, anorexia and weight loss, and mental disorders.

3.Some notes when using drugs to treat hepatitis B
Medical treatment may not be necessary for everyone with hepatitis B. Some cases of chronic hepatitis B do not develop serious complications and can live an active life without treatment. There are also cases where the liver is seriously damaged, requiring a liver transplant.

Medicines to treat hepatitis B can cause serious and long-term side effects. Therefore, patients need to strictly follow the doctor’s instructions regarding the type of medication and dosage to ensure safety and effective treatment.

Patients can take medication for a long time. Therefore, it is extremely necessary to visit a liver specialist every year. Patients need to perform regular tests to evaluate HBV activity. Common tests are: examination of hepatobiliary and digestive functions; blood microbiology test; cancer screening blood test; Serum liver enzyme testing; liver imaging (ultrasound, CT scan…)

Above are the most popular new generation hepatitis B treatment drugs today. It can be said that hepatitis B treatment helps prevent the proliferation and activity of HBV, thereby preventing the risk of liver damage and complications while also preventing transmission of pathogens to people around. In particular, patients should not buy medication on their own; they need advice and prescription from a specialist.

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